D27V (p.Asp27Val) variant of LPA (Apolipoprotein(a))
D27V (p.Asp27Val) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
D27V (p.Asp27Val) variant details
- p.Asp27Val
- TOPMed rs1219429589
- gnomAD rs1219429589
- Missense
- Variant Prioritization Score for Impact Estimate 0.286
- REVEL 0.08
- MetaLR 0.14
- MetaSVM -0.84
- CADD 24.00
- PolyPhen-2 0.60
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available