D27N (p.Asp27Asn) variant of LPA (Apolipoprotein(a))
D27N (p.Asp27Asn) in LPA (Apolipoprotein(a)) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
D27N (p.Asp27Asn) variant details
- p.Asp27Asn
- NCI-TCGA Cosmic COSV6030
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.274
- REVEL 0.08
- MetaLR 0.09
- MetaSVM -1.03
- CADD 18.20
- PolyPhen-2 0.32
- SIFT 0.08
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available