D221V (p.Asp221Val) variant of LPA (Apolipoprotein(a))
D221V (p.Asp221Val) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
D221V (p.Asp221Val) variant details
- p.Asp221Val
- gnomAD rs1231838924
- Missense
- Variant Prioritization Score for Impact Estimate 0.148
- REVEL 0.09
- MetaLR 0.07
- MetaSVM -1.09
- CADD 14.20
- PolyPhen-2 0.32
- SIFT 0.39
- Most common in the East Asian population (allele frequency 4.2e-05)
- Structural context available