A70T (p.Ala70Thr) variant of LPA (Apolipoprotein(a))
A70T (p.Ala70Thr) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
A70T (p.Ala70Thr) variant details
- p.Ala70Thr
- TOPMed rs967287601
- gnomAD rs967287601
- Missense
- Variant Prioritization Score for Impact Estimate 0.45
- REVEL 0.30
- MetaLR 0.28
- MetaSVM -0.81
- CADD 22.60
- PolyPhen-2 0.85
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available