P87R (p.Pro87Arg) variant of LOX (Protein-lysine 6-oxidase)
P87R (p.Pro87Arg) in LOX (Protein-lysine 6-oxidase) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
P87R (p.Pro87Arg) variant details
- p.Pro87Arg
- rs572413728
- ClinGen CA360877244
- ClinVar RCV003678794
- 1000Genomes rs572413728
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.144
- REVEL 0.05
- CADD 14.40
- PolyPhen-2 0.00
- SIFT 0.45
- ClinVar: Uncertain significance (not provided)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Latino/Admixed American population (allele frequency 2.5e-05)
- Structural context available