C21W (p.Cys21Trp) variant of LOX (Protein-lysine 6-oxidase)
C21W (p.Cys21Trp) in LOX (Protein-lysine 6-oxidase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
C21W (p.Cys21Trp) variant details
- p.Cys21Trp
- ExAC rs771172229
- TOPMed rs771172229
- gnomAD rs771172229
- Missense
- Variant Prioritization Score for Impact Estimate 0.267
- REVEL 0.10
- CADD 22.80
- PolyPhen-2 0.26
- SIFT 0.08
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available