T10S (p.Thr10Ser) variant of LMNA (Prelamin-A/C)
T10S (p.Thr10Ser) in LMNA (Prelamin-A/C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, published literature, and structural context.
T10S (p.Thr10Ser) variant details
- p.Thr10Ser
- gnomAD 1-156114946-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.31
- REVEL 0.23
- ESM-1b 0.00
- AlphaMissense 0.08
- MetaLR 0.21
- MetaSVM -0.84
- CADD 21.90
- Population evidence available
- Structural context available
- Literature evidence available