S17S (p.Ser17Ser) variant of LMNA (Prelamin-A/C)

Name: LMNA S17S (p.Ser17Ser) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-05-15
License: https://catvariant.com/terms-of-use

S17S (p.Ser17Ser) in LMNA (Prelamin-A/C) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, published literature, and structural context.

S17S (p.Ser17Ser) variant details

p.Ser17Ser
rs11549668
gnomAD 1-156114969-C-T
Synonymous
Variant Prioritization Score for Impact Estimate 0.361
CADD 14.30
Most common in the 1KG:CEU population (allele frequency 0.0042)
Structural context available
Cited in: Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American… (PMID 25741868)
Cited in: A systematic approach to assessing the clinical significance of genetic variants. (PMID 24033266)