W3C (p.Trp3Cys) variant of LEP (Leptin)
W3C (p.Trp3Cys) in LEP (Leptin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
W3C (p.Trp3Cys) variant details
- p.Trp3Cys
- NCI-TCGA Cosmic COSV1004
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0958
- REVEL 0.11
- CADD 0.32
- PolyPhen-2 0.00
- SIFT 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available