T37S (p.Thr37Ser) variant of LEP (Leptin)
T37S (p.Thr37Ser) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data, published literature, and structural context.
T37S (p.Thr37Ser) variant details
- p.Thr37Ser
- gnomAD 7-128252127-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.633
- REVEL 0.64
- CADD 24.20
- PolyPhen-2 0.99
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available