T31S (p.Thr31Ser) variant of LEP (Leptin)
T31S (p.Thr31Ser) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
T31S (p.Thr31Ser) variant details
- p.Thr31Ser
- TOPMed rs1795281972
- Missense
- Variant Prioritization Score for Impact Estimate 0.462
- REVEL 0.28
- CADD 20.00
- PolyPhen-2 0.08
- SIFT 0.07
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available