P90R (p.Pro90Arg) variant of LEP (Leptin)
P90R (p.Pro90Arg) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
P90R (p.Pro90Arg) variant details
- p.Pro90Arg
- TOPMed rs1206379074
- gnomAD rs1206379074
- Missense
- Variant Prioritization Score for Impact Estimate 0.263
- REVEL 0.21
- CADD 20.60
- PolyPhen-2 0.60
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available