P14L (p.Pro14Leu) variant of LEP (Leptin)
P14L (p.Pro14Leu) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
P14L (p.Pro14Leu) variant details
- p.Pro14Leu
- TOPMed rs1036136017
- gnomAD rs1036136017
- Missense
- Variant Prioritization Score for Impact Estimate 0.171
- REVEL 0.09
- CADD 6.62
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available