L86F (p.Leu86Phe) variant of LEP (Leptin)
L86F (p.Leu86Phe) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
L86F (p.Leu86Phe) variant details
- p.Leu86Phe
- ExAC rs748408158
- gnomAD rs748408158
- Missense
- Variant Prioritization Score for Impact Estimate 0.525
- REVEL 0.65
- CADD 16.90
- PolyPhen-2 0.55
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available