L66H (p.Leu66His) variant of LEP (Leptin)
L66H (p.Leu66His) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
L66H (p.Leu66His) variant details
- p.Leu66His
- TOPMed rs1795311621
- gnomAD rs1795311621
- Missense
- Variant Prioritization Score for Impact Estimate 0.351
- REVEL 0.40
- CADD 17.10
- PolyPhen-2 0.95
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available