L60W (p.Leu60Trp) variant of LEP (Leptin)
L60W (p.Leu60Trp) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data, published literature, and structural context.
L60W (p.Leu60Trp) variant details
- p.Leu60Trp
- gnomAD 7-128254438-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.626
- REVEL 0.69
- CADD 24.80
- PolyPhen-2 1.00
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available