L16V (p.Leu16Val) variant of LEP (Leptin)
L16V (p.Leu16Val) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
L16V (p.Leu16Val) variant details
- p.Leu16Val
- ExAC rs765869630
- gnomAD rs765869630
- Missense
- Variant Prioritization Score for Impact Estimate 0.365
- REVEL 0.34
- CADD 15.20
- PolyPhen-2 1.00
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available