I85V (p.Ile85Val) variant of LEP (Leptin)
I85V (p.Ile85Val) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, published literature, and structural context.
I85V (p.Ile85Val) variant details
- p.Ile85Val
- gnomAD 7-128254512-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.149
- REVEL 0.11
- CADD 8.65
- PolyPhen-2 0.07
- SIFT 0.31
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- Literature evidence available