I85F (p.Ile85Phe) variant of LEP (Leptin)
I85F (p.Ile85Phe) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
I85F (p.Ile85Phe) variant details
- p.Ile85Phe
- gnomAD rs1311825614
- Missense
- Variant Prioritization Score for Impact Estimate 0.433
- REVEL 0.52
- CADD 22.20
- PolyPhen-2 0.98
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available