I63L (p.Ile63Leu) variant of LEP (Leptin)
I63L (p.Ile63Leu) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
I63L (p.Ile63Leu) variant details
- p.Ile63Leu
- ExAC rs751272426
- TOPMed rs751272426
- gnomAD rs751272426
- Missense
- Variant Prioritization Score for Impact Estimate 0.332
- REVEL 0.36
- CADD 18.10
- PolyPhen-2 0.10
- SIFT 0.10
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00047)
- Structural context available