D29G (p.Asp29Gly) variant of LEP (Leptin)
D29G (p.Asp29Gly) in LEP (Leptin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
D29G (p.Asp29Gly) variant details
- p.Asp29Gly
- TOPMed rs1304598562
- gnomAD rs1304598562
- Missense
- Variant Prioritization Score for Impact Estimate 0.431
- REVEL 0.44
- CADD 22.60
- PolyPhen-2 0.65
- SIFT 0.12
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available