S51F (p.Ser51Phe) variant of KRT16 (Keratin, type I cytoskeletal 16)
S51F (p.Ser51Phe) in KRT16 (Keratin, type I cytoskeletal 16) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
S51F (p.Ser51Phe) variant details
- p.Ser51Phe
- NCI-TCGA Cosmic COSV5696
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.462
- REVEL 0.41
- CADD 23.90
- PolyPhen-2 0.72
- SIFT 0.18
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 8.8e-05)
- Structural context available