S39F (p.Ser39Phe) variant of KRT16 (Keratin, type I cytoskeletal 16)
S39F (p.Ser39Phe) in KRT16 (Keratin, type I cytoskeletal 16) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
S39F (p.Ser39Phe) variant details
- p.Ser39Phe
- NCI-TCGA Cosmic COSV5697
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.372
- REVEL 0.27
- CADD 22.70
- PolyPhen-2 0.10
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:CLM population (allele frequency 0.0053)
- Structural context available