G65W (p.Gly65Trp) variant of KRT16 (Keratin, type I cytoskeletal 16)
G65W (p.Gly65Trp) in KRT16 (Keratin, type I cytoskeletal 16) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
G65W (p.Gly65Trp) variant details
- p.Gly65Trp
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.595
- REVEL 0.54
- CADD 24.40
- PolyPhen-2 0.99
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:FRENCH population (allele frequency 0.019)
- Structural context available