Y4* (p.Tyr4Ter) variant of KRAS (GTPase KRas)
Y4* (p.Tyr4Ter) in KRAS (GTPase KRas) is a protein-truncating change. Clinical records from EBI and UniProt describe it as uncertain significance. The record also includes experimental measurements, published literature, and structural context.
Y4* (p.Tyr4Ter) variant details
- p.Tyr4Ter
- rs2548933405
- ClinGen CA384157539
- ClinVar RCV002292291
- Uncertain significance
- Stop Gained
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.0176
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)
- Cited in: Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. (PMID 31829902)