Y32S (p.Tyr32Ser) variant of KRAS (GTPase KRas)
Y32S (p.Tyr32Ser) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Prostate cancer, hereditary, 1. The record also includes experimental measurements, published literature, and structural context.
Y32S (p.Tyr32Ser) variant details
- p.Tyr32Ser
- rs2548933141
- ClinGen CA384157261
- ClinVar RCV002292327
- Uncertain significance
- Prostate cancer, hereditary, 1
- Missense
- ClinVar: Uncertain significance (Prostate cancer, hereditary, 1)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.0325
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)
- Cited in: Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. (PMID 31829902)