V8I (p.Val8Ile) variant of KRAS (GTPase KRas)
V8I (p.Val8Ile) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes experimental measurements and structural context.
V8I (p.Val8Ile) variant details
- p.Val8Ile
- rs2135806332
- ClinGen CA384157501
- cosmic curated COSV55592
- ClinVar RCV001355366
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.462
- AlphaMissense 0.51
- MetaLR 0.48
- MetaSVM -0.20
- PolyPhen-2 0.05
- SIFT 0.08
- EVE 0.28
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.507