V7M (p.Val7Met) variant of KRAS (GTPase KRas)
V7M (p.Val7Met) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes experimental measurements and structural context.
V7M (p.Val7Met) variant details
- p.Val7Met
- rs2135806349
- ClinGen CA384157511
- cosmic curated COSV56130
- ClinVar RCV001355312
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.664
- AlphaMissense 0.99
- MetaLR 0.67
- MetaSVM 0.42
- PolyPhen-2 1.00
- SIFT 0.00
- EVE 0.51
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.421