V44I (p.Val44Ile) variant of KRAS (GTPase KRas)
V44I (p.Val44Ile) in KRAS (GTPase KRas) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V44I (p.Val44Ile) variant details
- p.Val44Ile
- cosmic curated COSV55926
- Ensembl rs2141510495
- Missense
- Variant Prioritization Score for Impact Estimate 0.443
- REVEL 0.26
- MetaLR 0.33
- MetaSVM -0.52
- CADD 22.50
- PolyPhen-2 0.14
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.398