V14L (p.Val14Leu) variant of KRAS (GTPase KRas)
V14L (p.Val14Leu) in KRAS (GTPase KRas) is a missense change. Clinical records from EBI and UniProt describe it as pathogenic in the context of in NS3. The record also includes experimental measurements and structural context.
V14L (p.Val14Leu) variant details
- p.Val14Leu
- cosmic curated COSV10880
- ExAC rs104894365
- gnomAD rs104894365
- Pathogenic
- in NS3
- Missense
- EBI: Pathogenic (in NS3)
- UniProt: Pathogenic (in NS3)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.981