T2P (p.Thr2Pro) variant of KRAS (GTPase KRas)
T2P (p.Thr2Pro) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Cardiovascular phenotype. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes experimental measurements and structural context.
T2P (p.Thr2Pro) variant details
- p.Thr2Pro
- rs2135806400
- ClinGen CA384157599
- ClinVar RCV002343026
- Uncertain significance
- Cardiovascular phenotype
- Missense
- Variant Prioritization Score for Impact Estimate 0.541
- AlphaMissense 0.34
- MetaLR 0.65
- MetaSVM 0.06
- PolyPhen-2 0.00
- SIFT 0.12
- MutPred 0.31
- ClinVar: Uncertain significance (Cardiovascular phenotype)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.186