T20M (p.Thr20Met) variant of KRAS (GTPase KRas)
T20M (p.Thr20Met) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar and UniProt describe it as likely pathogenic in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.79 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T20M (p.Thr20Met) variant details
- p.Thr20Met
- cosmic curated COSV55571
- Ensembl rs2135805997
- Likely pathogenic
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.789
- REVEL 0.84
- MetaLR 0.64
- MetaSVM 0.34
- CADD 28.10
- PolyPhen-2 1.00
- SIFT 0.03
- ClinVar: Likely pathogenic (not provided)
- UniProt: Likely pathogenic
- Population evidence available
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.194