S39K (p.Ser39Lys) variant of KRAS (GTPase KRas)
S39K (p.Ser39Lys) in KRAS (GTPase KRas) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S39K (p.Ser39Lys) variant details
- p.Ser39Lys
- rs765963191
- gnomAD 12-25235216-C-CT
- Frameshift
- Variant Prioritization Score for Impact Estimate 0.151
- CADD 5.17
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.599
- Literature evidence available