R97K (p.Arg97Lys) variant of KRAS (GTPase KRas)
R97K (p.Arg97Lys) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely pathogenic in the context of Non-small cell lung carcinoma. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
R97K (p.Arg97Lys) variant details
- p.Arg97Lys
- rs727503106
- ClinGen CA176487
- ClinVar RCV000150887
- Ensembl rs727503106
- Likely pathogenic
- Non-small cell lung carcinoma
- Missense
- Variant Prioritization Score for Impact Estimate 0.523
- REVEL 0.38
- MetaLR 0.35
- MetaSVM -0.61
- CADD 32.00
- PolyPhen-2 0.03
- SIFT 0.00
- ClinVar: Likely pathogenic (Non-small cell lung carcinoma)
- EBI: Likely pathogenic
- UniProt: Likely pathogenic
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- binding fitness from KRAS-DARPin K27 bindingPCA of KRAS block2: score -0.226
- Cited in: Guideline Recommendations for EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology… (PMID 23667368)
- Cited in: Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean… (PMID 24627688)