R68S (p.Arg68Ser) variant of KRAS (GTPase KRas)
R68S (p.Arg68Ser) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar and UniProt describe it as pathogenic/likely pathogenic in the context of RASopathy; Cardiofaciocutaneous syndrome 2; Noonan syndrome 3. The record also includes experimental measurements and structural context.
R68S (p.Arg68Ser) variant details
- p.Arg68Ser
- NCI-TCGA Cosmic COSV5564
- cosmic curated COSV55640
- NCI-TCGA Cosmic COSV5565
- Pathogenic/Likely pathogenic
- RASopathy; Cardiofaciocutaneous syndrome 2; Noonan syndrome 3
- Missense
- ClinVar: Pathogenic/Likely pathogenic (RASopathy; Cardiofaciocutaneous syndrome 2; Noonan syndrome 3)
- UniProt: Likely pathogenic
- Structural context available
- binding fitness from KRAS-DARPin K27 bindingPCA of KRAS block2: score -0.164