R41S (p.Arg41Ser) variant of KRAS (GTPase KRas)
R41S (p.Arg41Ser) in KRAS (GTPase KRas) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R41S (p.Arg41Ser) variant details
- p.Arg41Ser
- Ensembl rs2141510521
- Missense
- Variant Prioritization Score for Impact Estimate 0.525
- REVEL 0.60
- MetaLR 0.47
- MetaSVM -0.17
- CADD 24.20
- PolyPhen-2 0.95
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.409