Q61K (p.Gln61Lys) variant of KRAS (GTPase KRas)
Q61K (p.Gln61Lys) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as conflicting interpretations in the context of Autosomal dominant KRAS-related disorders; Cardiovascular phenotype. The record also includes experimental measurements, published literature, and structural context.
Q61K (p.Gln61Lys) variant details
- p.Gln61Lys
- rs2141510126
- ClinGen CA645572098
- ClinVar RCV004412079
- ClinVar RCV006254398
- Conflicting interpretations
- Autosomal dominant KRAS-related disorders; Cardiovascular phenotype
- Missense
- ClinVar: Conflicting classifications of pathogenicity (Autosomal dominant KRAS-related disorders; Cardiovascular phenot)
- EBI: Variant of uncertain significance (in a colorectal cancer sample)
- UniProt: Uncertain significance (in a colorectal cancer sample)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.202
- Cited in: Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version. (PMID 26389258)
- Cited in: Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®): Health Professional Version. (PMID 26389271)