Q43H (p.Gln43His) variant of KRAS (GTPase KRas)
Q43H (p.Gln43His) in KRAS (GTPase KRas) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
Q43H (p.Gln43His) variant details
- p.Gln43His
- gnomAD 12-25227395-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.454
- REVEL 0.45
- MetaLR 0.34
- MetaSVM -0.41
- CADD 23.20
- PolyPhen-2 0.21
- SIFT 0.15
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.799
- Literature evidence available