Q25R (p.Gln25Arg) variant of KRAS (GTPase KRas)
Q25R (p.Gln25Arg) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data, experimental measurements, and structural context.
Q25R (p.Gln25Arg) variant details
- p.Gln25Arg
- rs2135805919
- ClinGen CA384157340
- ClinVar RCV001358141
- Ensembl rs2135805919
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.625
- REVEL 0.69
- AlphaMissense 0.93
- MetaLR 0.46
- MetaSVM -0.00
- CADD 26.90
- PolyPhen-2 1.00
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.288