Q25L (p.Gln25Leu) variant of KRAS (GTPase KRas)
Q25L (p.Gln25Leu) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Prostate cancer, hereditary, 1. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes experimental measurements, published literature, and structural context.
Q25L (p.Gln25Leu) variant details
- p.Gln25Leu
- rs2135805919
- ClinGen CA384157339
- ClinVar RCV002292316
- Uncertain significance
- Prostate cancer, hereditary, 1
- Missense
- Variant Prioritization Score for Impact Estimate 0.476
- AlphaMissense 0.93
- MetaLR 0.46
- MetaSVM -0.00
- PolyPhen-2 1.00
- SIFT 0.00
- EVE 0.33
- ClinVar: Uncertain significance (Prostate cancer, hereditary, 1)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.288
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)
- Cited in: Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. (PMID 31829902)