Q22* (p.Gln22Ter) variant of KRAS (GTPase KRas)
Q22* (p.Gln22Ter) in KRAS (GTPase KRas) is a protein-truncating change. Clinical records from EBI and UniProt describe it as pathogenic in the context of in NS3. The record also includes experimental measurements, published literature, and structural context.
Q22* (p.Gln22Ter) variant details
- p.Gln22Ter
- Civic 479
- cosmic curated COSV55779
- Ensembl rs121913236
- Pathogenic
- in NS3
- Stop Gained
- EBI: Pathogenic (in NS3)
- UniProt: Pathogenic (in NS3)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.699
- Cited in: A novel K-ras mutation in colorectal cancer. A case report and literature review. (PMID 19661358)