N26T (p.Asn26Thr) variant of KRAS (GTPase KRas)
N26T (p.Asn26Thr) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Prostate cancer, hereditary, 1. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes experimental measurements, published literature, and structural context.
N26T (p.Asn26Thr) variant details
- p.Asn26Thr
- rs2135805894
- ClinGen CA384157328
- ClinVar RCV002292318
- Uncertain significance
- Prostate cancer, hereditary, 1
- Missense
- Variant Prioritization Score for Impact Estimate 0.704
- AlphaMissense 0.99
- MetaLR 0.68
- MetaSVM 0.59
- PolyPhen-2 0.91
- SIFT 0.00
- EVE 0.64
- ClinVar: Uncertain significance (Prostate cancer, hereditary, 1)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.404
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)
- Cited in: Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. (PMID 31829902)