K5* (p.Lys5Ter) variant of KRAS (GTPase KRas)
K5* (p.Lys5Ter) in KRAS (GTPase KRas) is a protein-truncating change. Clinical records from EBI and UniProt describe it as uncertain significance in the context of in GASC. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes experimental measurements, published literature, and structural context.
K5* (p.Lys5Ter) variant details
- p.Lys5Ter
- rs193929331
- ClinGen CA384157535
- ClinVar RCV002292292
- Uncertain significance
- in GASC
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.779
- AlphaMissense 0.99
- MetaLR 0.84
- MetaSVM 0.96
- PolyPhen-2 1.00
- SIFT 0.00
- EVE 0.42
- EBI: Variant of uncertain significance (in GASC)
- UniProt: Uncertain significance (in GASC)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.893
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)
- Cited in: Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. (PMID 31829902)