I46M (p.Ile46Met) variant of KRAS (GTPase KRas)
I46M (p.Ile46Met) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of RASopathy. The record also includes experimental measurements and structural context.
I46M (p.Ile46Met) variant details
- p.Ile46Met
- TOPMed rs904755552
- Uncertain significance
- RASopathy
- Missense
- ClinVar: Uncertain significance (RASopathy)
- UniProt: Uncertain significance
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.59