I36V (p.Ile36Val) variant of KRAS (GTPase KRas)
I36V (p.Ile36Val) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes experimental measurements and structural context.
I36V (p.Ile36Val) variant details
- p.Ile36Val
- rs2135805722
- ClinGen CA384157222
- ClinVar RCV003233234
- Ensembl rs2135805722
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.435
- AlphaMissense 0.84
- MetaLR 0.48
- MetaSVM -0.00
- PolyPhen-2 0.19
- SIFT 0.00
- EVE 0.21
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance (in NS3)
- UniProt: Uncertain significance (in NS3)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.453