I36K (p.Ile36Lys) variant of KRAS (GTPase KRas)
I36K (p.Ile36Lys) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Prostate cancer, hereditary, 1. The available variant effect predictions contribute to a CATVariant prioritization score of 0.72 / 1. The record also includes experimental measurements, published literature, and structural context.
I36K (p.Ile36Lys) variant details
- p.Ile36Lys
- rs2135805713
- ClinGen CA384157219
- ClinVar RCV002292263
- Ensembl rs2135805713
- Uncertain significance
- Prostate cancer, hereditary, 1
- Missense
- Variant Prioritization Score for Impact Estimate 0.724
- AlphaMissense 1.00
- MetaLR 0.80
- MetaSVM 0.86
- PolyPhen-2 0.76
- SIFT 0.07
- EVE 0.32
- ClinVar: Uncertain significance (Prostate cancer, hereditary, 1)
- EBI: Variant of uncertain significance (in NS3)
- UniProt: Uncertain significance (in NS3)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.453
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)
- Cited in: Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. (PMID 31829902)