G15V (p.Gly15Val) variant of KRAS (GTPase KRas)
G15V (p.Gly15Val) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely pathogenic in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.91 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G15V (p.Gly15Val) variant details
- p.Gly15Val
- rs1555195579
- ClinGen CA384157440
- ClinVar RCV000521534
- Ensembl rs1555195579
- Likely pathogenic
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.906
- REVEL 0.96
- MetaLR 0.99
- MetaSVM 0.97
- CADD 25.80
- PolyPhen-2 0.99
- SIFT 0.00
- ClinVar: Likely pathogenic (not provided)
- EBI: Likely pathogenic
- UniProt: Likely pathogenic
- Population evidence available
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -1.19