G13R (p.Gly13Arg) variant of KRAS (GTPase KRas)
G13R (p.Gly13Arg) in KRAS (GTPase KRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as pathogenic in the context of not provided. The record also includes experimental measurements, published literature, and structural context.
G13R (p.Gly13Arg) variant details
- p.Gly13Arg
- Ensembl rs2135806161
- Pathogenic
- not provided
- Missense
- ClinVar: Pathogenic (not provided)
- EBI: Pathogenic (in pylocytic astrocytoma)
- UniProt: Pathogenic (in pylocytic astrocytoma)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.346
- Cited in: RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma. (PMID 16247081)