G13A (p.Gly13Ala) variant of KRAS (GTPase KRas)
G13A (p.Gly13Ala) in KRAS (GTPase KRas) is a missense change. Clinical records from EBI and UniProt describe it as pathogenic in the context of in pylocytic astrocytoma. The record also includes experimental measurements and structural context.
G13A (p.Gly13Ala) variant details
- p.Gly13Ala
- cosmic curated COSV55497
- gnomAD rs112445441
- Pathogenic
- in pylocytic astrocytoma
- Missense
- EBI: Pathogenic (in pylocytic astrocytoma)
- UniProt: Pathogenic (in pylocytic astrocytoma)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.346