E37E (p.Glu37Glu) variant of KRAS (GTPase KRas)
E37E (p.Glu37Glu) in KRAS (GTPase KRas) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
E37E (p.Glu37Glu) variant details
- p.Glu37Glu
- rs1592808357
- gnomAD 12-25227335-C-T
- Splice Region
- Variant Prioritization Score for Impact Estimate 0.334
- AlphaMissense 0.97
- MetaLR 0.31
- MetaSVM -0.59
- CADD 9.28
- PolyPhen-2 0.01
- SIFT 0.16
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- abundance fitness from abundancePCA of KRAS block1: score -0.565
- Literature evidence available